25. Subcellular localization of protein phosphatase type 1δ isotypes and AgNORs in mouse osteoblastic cells
نویسندگان
چکیده
منابع مشابه
Interaction of Protein Phosphatase 1δ with Nucleophosmin in Human Osteoblastic Cells
Protein phosphorylation and dephosphorylation has been recognized as an essential mechanism in the regulation of cellular metabolism and function in various tissues. Serine and threonine protein phosphatases (PP) are divided into four categories: PP1, PP2A, PP2B, and PP2C. At least four isoforms of PP1 catalytic subunit in rat, PP1α, PP1γ1, PP1γ2, and PP1δ, were isolated. In the present study, ...
متن کاملLOCATE: a mouse protein subcellular localization database
We present here LOCATE, a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of proteins from the FANTOM3 Isoform Protein Sequence set. Membrane organization is predicted by the high-throughput, computational pipeline MemO. The subcellular locations of selected proteins from this set were determined by a high-throughput, immunoflu...
متن کاملProtein Subcellular Localization Prediction
ORGANIZATION. Section 1. We first provide the motivation for prediction of protein subcellular localization sites, as well as discuss changes being brought about by progress in proteomics. Section 2. After that, we describe the biology of protein subcellular location. In particular, we explain the principle of protein sorting signals. Section 3. Then we present several experimental techniques f...
متن کاملRefining Protein Subcellular Localization
The study of protein subcellular localization is important to elucidate protein function. Even in well-studied organisms such as yeast, experimental methods have not been able to provide a full coverage of localization. The development of bioinformatic predictors of localization can bridge this gap. We have created a Bayesian network predictor called PSLT2 that considers diverse protein charact...
متن کاملDifferential Subcellular Localization of Protein Phosphatase-1 α, γ1, and δ Isoforms during Both Interphase and Mitosis in Mammalian Cells
Protein phosphatase-1 (PP-1) is involved in the regulation of numerous metabolic processes in mammalian cells. The major isoforms of PP-1, alpha, gamma1, and delta, have nearly identical catalytic domains, but they vary in sequence at their extreme NH2 and COOH termini. With specific antibodies raised against the unique COOH-terminal sequence of each isoform, we find that the three PP-1 isoform...
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ژورنال
عنوان ژورنال: The Journal of the Kyushu Dental Society
سال: 1999
ISSN: 0368-6833,1880-8719
DOI: 10.2504/kds.53.736_1